›› 2011, Vol. 23 ›› Issue (4): 287-290.doi: 10.3969/j.issn.1004-616x.2011.04.010

• 论著 • Previous Articles     Next Articles

The association of cervical lesion pathogenesis in Uighur women with the protein expression of calcitonin- related polypeptide alpha

SHENG Lei，HASIMU·Axiangu，LIU Kai-jiang，ABUDULA·Abulizi*   

  1. 1. Key Laboratory of Molecular Biology and Endemic Diseases of the Autonomous Region, Xinjiang Medical University, Urumqi 830011; 2. Department of Pathology, Xinjiang Medical University, Urumqi 830011; 3. Department of Gynaecology of the Affiliated Tumor Hospital, Xinjiang Medical University, Urumqi 830054, China
  • Received:2011-02-22 Revised:2011-04-18 Online:2011-07-30 Published:2011-07-30
  • Contact: ABUDULA·Abulizi

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Abstract: OBJECTIVE: To investigate the association of calcitonin-related polypeptide alpha (CALCA) protein expression level with cervical lesion pathogenesis. METHODS：We collected 104 cases of paraffin-embedded cervical tissue specimens of Uighur women with cervicitis，low grade squamous intraepithelial lesion (LSIL)，high grade squamous intraepithelial lesion ( HSIL) and cervical squamous cell carcinoma (CSCC)，and evaluated the CALCA protein expression by immunohistochemistry. RESULTS：CALCA protein was strongly expressed by cervical epithelial cells in most cases of cervicitis，but the expression level changed from strong to weak or loss of expressions with the development of cervical intraepithelial neoplasia and cervical carcinoma. The rates of CALCA protein expression loss in the groups of cervicitis，LSIL，HSIL and CSCC were 45.5% (15/33)，75% (12/16)，80.8% (21/26)and 82.8% (24/29)，respectively. The expression level was negatively correlated with cervical lesion pathogenesis (r = -0.361，P<0.01)，and the difference was statistically significant for HSIL and CSCC compared to cervicitis (P＜0.01)，but not for LSIL (P＞0.05). CONCLUSION：This study showed that the loss of CALCA protein expression was to some extent，associated with the development of cervical pre-cancerous lesions and cancer.

Key words: CALCA, cervical squamous cell carcinoma, immunohistochemistry, Uighur women